Interleukin-1 receptor antagonist gene (IL-1RN) polymorphism is a predictive factor of clinical pregnancy after IVF | Zendy

Sandrine Gremlich | Zendy; Stefania Fratta | Zendy; E. Rebellato | Zendy; R. Uras | Zendy; D. Reymondin | Zendy; F. Dam | Zendy; M. Germond | Zendy; Stefan Gerber | Zendy

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Interleukin-1 receptor antagonist gene (IL-1RN) polymorphism is a predictive factor of clinical pregnancy after IVF

Author(s) -

Sandrine Gremlich,

Stefania Fratta,

E. Rebellato,

R. Uras,

D. Reymondin,

F. Dam,

M. Germond,

Stefan Gerber

Publication year - 2008

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/den034

Subject(s) - odds ratio , pregnancy , medicine , single nucleotide polymorphism , obstetrics , confidence interval , gynecology , biology , genetics , gene , genotype

Only 25% of IVF transfer cycles lead to a clinical pregnancy, calling for continued technical progress but also more in depth analysis of patients' individual characteristics. The interleukin-1 (IL-1) system and matrix metalloproteinases (MMPs) are strongly implicated in embryo implantation. The genes coding for IL-1Ra (gene symbol IL-1RN), IL-1beta, MMP2 and MMP9 bear functional polymorphisms. We analysed the maternal genetic profile at these polymorphic sites in IVF patients, to determine possible correlations with IVF outcome.

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