Open AccessSoluble vascular endothelial-cadherin levels correlate with clinical and biological aspects of severe ovarian hyperstimulation syndrome
Author(s) -
A. Villasante,
A. Pacheco,
E. Pau,
Amparo Ruı́z,
A. Pellicer,
Juan A. García-Velasco
Publication year - 2008
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/dem429
Subject(s) - ovarian hyperstimulation syndrome , corpus luteum , vascular endothelial growth factor , adherens junction , medicine , vascular permeability , ve cadherin , endocrinology , pathogenesis , pathophysiology , cadherin , andrology , in vitro fertilisation , biology , ovary , vegf receptors , embryo , genetics , cell , microbiology and biotechnology
Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic complication of ovarian stimulation, and the pathophysiological mechanisms that trigger the syndrome remain unknown. HCG increases serum vascular endothelial growth factor (VEGF) concentrations, and VEGF modulates transendothelial permeability via endothelial adherens junctions, a downstream target for VEGF signalling. We examined whether women with severe OHSS have altered serum levels of soluble vascular endothelial (sVE)-cadherin.