Open AccessToward gene therapy of uterine fibroids: targeting modified adenovirus to human leiomyoma cells
Author(s) -
Memy H. Hassan,
Nilufar Khatoon,
David T. Curiel,
F.M. Hamada,
Hossam M.M. Arafa,
Ayman AlHendy
Publication year - 2008
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/dem410
Subject(s) - biology , genetic enhancement , cell culture , viral vector , microbiology and biotechnology , adenoviridae , cancer research , virology , recombinant dna , gene , biochemistry , genetics
To circumvent the paucity of the primary adenovirus (Ad5) receptor and the non-specific Ad5 tropism in the context of uterine leiomyoma cells, Ad5 modification strategies would be beneficial.
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