A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause | Zendy

Karl R. Hansen | Zendy; Nicholas Knowlton | Zendy; Angela Thyer | Zendy; Jay S. Charleston | Zendy; Michael R. Soules | Zendy; N.A. Klein | Zendy

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A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause

Author(s) -

Karl R. Hansen,

Nicholas Knowlton,

Angela Thyer,

Jay S. Charleston,

Michael R. Soules,

N.A. Klein

Publication year - 2008

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dem408

Subject(s) - menopause , stereology , ovarian follicle , folliculogenesis , biology , ovary , ovarian reserve , endocrinology , senescence , medicine , andrology , gynecology , pregnancy , infertility , lactation , genetics

The primary determinant of reproductive age in women is the number of ovarian non-growing (primordial, intermediate and primary) follicles (NGFs). To better characterize the decline in NGF number associated with aging, we have employed modern stereology techniques to determine NGF number in women from birth to menopause.

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