Effects of recombinant LH treatment on folliculogenesis and responsiveness to FSH stimulation | Zendy

Cedrin Durnerin | Zendy; Karin Erb | Zendy; R. Fleming | Zendy; H. Hillier | Zendy; Stephen G. Hillier | Zendy; Colin M. Howles | Zendy; JeanNoël Hugues | Zendy; Amir Lass | Zendy; Helen Lyall | Zendy; Pernille Rasmussen | Zendy; J. Thong | Zendy; I. Traynor | Zendy; Lars Westergaard | Zendy; R Yates | Zendy

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Effects of recombinant LH treatment on folliculogenesis and responsiveness to FSH stimulation

Author(s) -

Cedrin Durnerin,

Karin Erb,

R. Fleming,

H. Hillier,

Stephen G. Hillier,

Colin M. Howles,

JeanNoël Hugues,

Amir Lass,

Helen Lyall,

Pernille Rasmussen,

J. Thong,

I. Traynor,

Lars Westergaard,

R Yates

Publication year - 2007

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dem388

Subject(s) - antral follicle , follicular phase , stimulation , endocrinology , medicine , luteinizing hormone , hormone , folliculogenesis , agonist , follicle stimulating hormone , gonadotropin , andrology , biology , embryo , embryogenesis , receptor , microbiology and biotechnology

The role of LH in sensitizing antral follicles to FSH is unclear. LH is required for normal hormone production and normal oocyte and embryo development, but follicular responses to LH may depend upon the stage of development. Potential roles at the early follicular phase were explored in a clinical setting by employing a sequential approach to stimulation by recombinant human (r-h) LH followed by r-hFSH in women who were profoundly down-regulated by depo GnRH agonist.

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