Gene expression in human cumulus cells: one approach to oocyte competence | Zendy

Prisca P. Feuerstein | Zendy; Véronique Cadoret | Zendy; Rozenn DalbièsTran | Zendy; Fabrice Guérif | Zendy; Rudy Bidault | Zendy; Dominique Royère | Zendy

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Gene expression in human cumulus cells: one approach to oocyte competence

Author(s) -

Prisca P. Feuerstein,

Véronique Cadoret,

Rozenn DalbièsTran,

Fabrice Guérif,

Rudy Bidault,

Dominique Royère

Publication year - 2007

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dem336

Subject(s) - oocyte , blastocyst , biology , andrology , embryo , cumulus oophorus , gene expression , germinal vesicle , microbiology and biotechnology , intracytoplasmic sperm injection , embryogenesis , gene , genetics , in vitro fertilisation , medicine

Dialogue between the oocyte and cumulus cells is essential for oocyte maturation. A prospective laboratory research project was designed to evaluate transcription of specific genes in cumulus cells harvested before intracytoplasmic sperm injection from pre-ovulatory follicles, according to individual oocyte nuclear maturity and developmental competence. Genes were chosen because their expression was induced by the LH peak [Steroidogenic Acute Regulatory protein (STAR), Cyclooxygenase 2 (COX2 or PTGS2), Amphiregulin (AREG)] or because they were involved in oocyte lipidic metabolism [Stearoyl-Coenzyme A Desaturase 1 and 5 (SCD1 and SCD5)] or in gap-junctions [Connexin 43 (CX43 or GJA1)].

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