Human decidual stromal cells express HLA-G Effects of cytokines and decidualization | Zendy

Osmany Blanco | Zendy; Irene TiradoCabrera | Zendy; Raquel MuñozFernández | Zendy; Ana Clara AbadíaMolina | Zendy; José Marcos García-Pacheco | Zendy; José Peña | Zendy; Enrique G. Olivares | Zendy

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Human decidual stromal cells express HLA-G Effects of cytokines and decidualization

Author(s) -

Osmany Blanco,

Irene TiradoCabrera,

Raquel MuñozFernández,

Ana Clara AbadíaMolina,

José Marcos García-Pacheco,

José Peña,

Enrique G. Olivares

Publication year - 2007

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dem326

Subject(s) - decidualization , stromal cell , decidual cells , decidua , human leukocyte antigen , immunology , hla g , microbiology and biotechnology , biology , pregnancy , cancer research , antigen , placenta , fetus , genetics

Decidual stromal cells (DSC) are the main cellular component of the decidua, the maternal tissue in close contact with fetal trophoblast. Although of mesenchymal origin, DSC exert numerous immune functions that seem to be relevant for the immunological relationship between the mother and fetus. HLA-G, an antigen preferentially expressed by trophoblast, appears to participate in the immune tolerance by the mother of the semiallogeneic fetus.

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