Menstrual-like changes in mice are provoked through the pharmacologic withdrawal of progesterone using mifepristone following induction of decidualization | Zendy

Xiangbo Xu | Zendy; Bin He | Zendy; J.D. Wang | Zendy

Open Access

Menstrual-like changes in mice are provoked through the pharmacologic withdrawal of progesterone using mifepristone following induction of decidualization

Author(s) -

Xiangbo Xu,

Bin He,

J.D. Wang

Publication year - 2007

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dem312

Subject(s) - mifepristone , decidualization , menstruation , decidua , progesterone receptor , endometrium , abortifacient , endocrinology , medicine , mechanism of action , pregnancy , biology , placenta , fetus , genetics , cancer , estrogen receptor , breast cancer , biochemistry , in vitro

Cyclic shedding of the endometrium is unique to menstruating species, and mouse menstruation models by physiologic progesterone withdrawal have been previously reported. Since progesterone action ablated pharmacologically may provide more insight into the mechanism of action, a mouse menstruation model using mifepristone was established.

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