Inhibition of steroid sulphatase activity in endometriotic implants by 667 COUMATE: a potential new therapy | Zendy

A. Purohit | Zendy; Luca Fusi | Zendy; Jan J. Brosens | Zendy; L. W. Lawrence Woo | Zendy; B. V. L. POTTER | Zendy; Michael Reed | Zendy

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Inhibition of steroid sulphatase activity in endometriotic implants by 667 COUMATE: a potential new therapy

Author(s) -

A. Purohit,

Luca Fusi,

Jan J. Brosens,

L. W. Lawrence Woo,

B. V. L. POTTER,

Michael Reed

Publication year - 2007

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dem308

Subject(s) - aromatase , endometriosis , medicine , endocrinology , steroid sulfatase , estrogen , aromatase inhibitor , steroid , chemistry , hormone , cancer , breast cancer

Local biosynthesis of estrogens is thought to be important for the maintenance and growth of endometriotic implants. In addition to the formation of estrogen via the aromatase pathway, steroid sulphatase (STS), which is responsible for the hydrolysis of estrogen sulphates, may be an important source of estrogens in endometriosis.

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