Environmental toxicant-induced germ cell apoptosis in the human fetal testis | Zendy

Shiona M. Coutts | Zendy; N. Fulton | Zendy; Richard A. Anderson | Zendy

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Environmental toxicant-induced germ cell apoptosis in the human fetal testis

Author(s) -

Shiona M. Coutts,

N. Fulton,

Richard A. Anderson

Publication year - 2007

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dem300

Subject(s) - germ cell , spermatogenesis , biology , apoptosis , endocrinology , medicine , aryl hydrocarbon receptor , toxicant , fetus , andrology , pregnancy , toxicity , genetics , transcription factor , gene

Disorders of the male reproductive system are increasing in prevalence. The term testicular dysgenesis syndrome emphasizes the importance of developmental influences on the aetiology of conditions including cryptorchidism, testicular germ cell cancer and reduced spermatogenesis. Men whose mothers smoked during pregnancy have lower sperm production. Cigarette smoke contains agents acting on the aryl hydrocarbon receptor (AHR). We have investigated the presence of AHR in the developing human testis and the effects of functional activation.

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