A survey of assisted reproductive technology births and imprinting disorders | Zendy

Sarah Bowdin | Zendy; Cathy Allen | Zendy; Gail Kirby | Zendy; Louise Brueton | Zendy; Masoud Afnan | Zendy; Christopher L. R. Barratt | Zendy; Jackson KirkmanBrown | Zendy; Robert F. Harrison | Zendy; Eamonn R. Maher | Zendy; William Reardon | Zendy

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A survey of assisted reproductive technology births and imprinting disorders

Author(s) -

Sarah Bowdin,

Cathy Allen,

Gail Kirby,

Louise Brueton,

Masoud Afnan,

Christopher L. R. Barratt,

Jackson KirkmanBrown,

Robert F. Harrison,

Eamonn R. Maher,

William Reardon

Publication year - 2007

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dem268

Subject(s) - genomic imprinting , imprinting (psychology) , angelman syndrome , assisted reproductive technology , allele , epigenetics , medicine , cohort , uniparental disomy , genetics , pregnancy , gene , biology , dna methylation , infertility , chromosome , gene expression , karyotype

Genomic imprinting is an epigenetic process in which allele-specific gene expression is dependent on the parental inheritance. Although only a minority of human genes are imprinted, those that have been identified to date have been preferentially implicated in prenatal growth and neurodevelopment. Mutations or epimutations in imprinted genes or imprinting control centres are associated with imprinting disorders such as Angelman syndrome (AS) and Beckwith-Wiedemann syndrome (BWS). Recently, an increased frequency of assisted reproductive technology (ART) conceptions has been reported in children with BWS and AS. However, the risk of imprinting disorders in ART children is unknown.

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