Dual repressive effect of angiotensin II-type 1 receptor blocker telmisartan on angiotensin II-induced and estradiol-induced uterine leiomyoma cell proliferation | Zendy

Akihiko ISOBE | Zendy; Takashi Takeda | Zendy; Masahiro Sakata | Zendy; Akira Miyake | Zendy; T. Yamamoto | Zendy; Ryoko Minekawa | Zendy; Fumihito Nishimoto | Zendy; Y. Oskamoto | Zendy; Cheryl L. Walker | Zendy; Tadashi Kimura | Zendy

Open Access

Dual repressive effect of angiotensin II-type 1 receptor blocker telmisartan on angiotensin II-induced and estradiol-induced uterine leiomyoma cell proliferation

Author(s) -

Akihiko ISOBE,

Takashi Takeda,

Masahiro Sakata,

Akira Miyake,

T. Yamamoto,

Ryoko Minekawa,

Fumihito Nishimoto,

Y. Oskamoto,

Cheryl L. Walker,

Tadashi Kimura

Publication year - 2007

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dem247

Subject(s) - uterine leiomyoma , angiotensin ii , leiomyoma , endocrinology , cell growth , medicine , telmisartan , angiotensin receptor , receptor , myometrium , angiotensin ii receptor type 1 , renin–angiotensin system , biology , uterus , pathology , blood pressure , biochemistry

Although uterine leiomyomas or fibroids are the most common gynecological benign tumor and greatly affect reproductive health and well-being, the pathophysiology and epidemiology of uterine leiomyomas are poorly understood. Elevated blood pressure has an independent, positive association with risk for clinically detected uterine leiomyoma. Angiotensin II (Ang II) is a key biological peptide in the renin-angiotensin system that regulates blood pressure.

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