Genetic polymorphisms on the factor V gene in women with recurrent miscarriage and acquired APCR | Zendy

F. Dawood | Zendy; R. Mountford | Zendy; R. G. Farquharson | Zendy; Siobhan Quenby | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Genetic polymorphisms on the factor V gene in women with recurrent miscarriage and acquired APCR

Author(s) -

F. Dawood,

R. Mountford,

R. G. Farquharson,

Siobhan Quenby

Publication year - 2007

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dem210

Subject(s) - single nucleotide polymorphism , thrombophilia , factor v , recurrent miscarriage , genetics , activated protein c resistance , miscarriage , biology , medicine , factor v leiden , gene , genotype , pregnancy , thrombosis , venous thrombosis

Recurrent miscarriage (RM) has been associated with the thrombophilia, activated protein C resistance (APCR). The factor V Leiden mutation located on the B domain of the factor V gene, causes 95% of APCR and since the B domain is pivotal to APCR, it seemed plausible that other mutations or polymorphisms affecting this active domain may instigate acquired APCR. The objective of this study was to determine whether other polymorphisms exist on the parts of the gene encoding the B domain of the factor V in women with acquired APCR and RM.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research