Effect of heparin and fractionated heparin on trophoblast invasion | Zendy

Ramesh Ganapathy | Zendy; Guy Whitley | Zendy; Judith E. Cartwright | Zendy; Philip R. Dash | Zendy; B. Thilaganathan | Zendy

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Effect of heparin and fractionated heparin on trophoblast invasion

Author(s) -

Ramesh Ganapathy,

Guy Whitley,

Judith E. Cartwright,

Philip R. Dash,

B. Thilaganathan

Publication year - 2007

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dem201

Subject(s) - trophoblast , heparin , thrombophilia , pregnancy , anticoagulant , medicine , antiphospholipid syndrome , andrology , immunology , obstetrics , biology , placenta , fetus , antibody , genetics

Heparin can significantly reduce pregnancy complications in women with certain thrombophilias, such as antiphospholipid syndrome. Recent reports suggest that heparin may act by mechanisms other than anticoagulation. However, the effect of heparin on trophoblast biology in the absence of thrombophilia has not been extensively investigated. Therefore, this study aimed to evaluate trophoblast invasion, using an established cell line and primary extravillous trophoblasts (EVTs), following exposure to heparin and fractionated heparin.

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