Stimulatory and inhibitory effects of genistein on human uterine leiomyoma cell proliferation are influenced by the concentration | Zendy

Alicia B. Moore | Zendy; Lisandra Castro | Zendy; Linda ChiaHui Yu | Zendy; Xiaolin Zheng | Zendy; Xudong Di | Zendy; Maria I. Sifre | Zendy; Grace E. Kissling | Zendy; Retha R. Newbold | Zendy; Carl D. Bortner | Zendy; Darlene Dixon | Zendy

Open Access

Stimulatory and inhibitory effects of genistein on human uterine leiomyoma cell proliferation are influenced by the concentration

Author(s) -

Alicia B. Moore,

Lisandra Castro,

Linda ChiaHui Yu,

Xiaolin Zheng,

Xudong Di,

Maria I. Sifre,

Grace E. Kissling,

Retha R. Newbold,

Carl D. Bortner,

Darlene Dixon

Publication year - 2007

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dem185

Subject(s) - genistein , apoptosis , proliferating cell nuclear antigen , cell growth , biology , flow cytometry , uterine leiomyoma , estrogen , endocrinology , cell culture , immunocytochemistry , cell cycle , medicine , microbiology and biotechnology , uterus , biochemistry , genetics

Due to dietary exposure of women to genistein, a soy-derived phytoestrogen, and the estrogen responsiveness of uterine leiomyomas 'fibroids', we evaluated the effects of genistein (0.001-50 microg/ml) on human uterine leiomyoma (UtLM) cells versus uterine smooth muscle cells (UtSMCs) in vitro.

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