Soluble MHC Class I chain-related molecule serum levels are predictive markers of implantation failure and successful term pregnancies following IVF | Zendy

G. Porcu-Buisson | Zendy; M. Lambert | Zendy; Luc Lyonnet | Zendy; A. Loundou | Zendy; M. Gamerre | Zendy; Laurence CamoinJau | Zendy; Françoise DignatGeorge | Zendy; Sophie CaillatZucman | Zendy; Pascale Paul | Zendy

Open Access

Soluble MHC Class I chain-related molecule serum levels are predictive markers of implantation failure and successful term pregnancies following IVF

Author(s) -

G. Porcu-Buisson,

M. Lambert,

Luc Lyonnet,

A. Loundou,

M. Gamerre,

Laurence CamoinJau,

Françoise DignatGeorge,

Sophie CaillatZucman,

Pascale Paul

Publication year - 2007

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dem157

Subject(s) - implantation failure , major histocompatibility complex , mhc class i , pregnancy , predictive marker , regulator , immunology , medicine , biology , andrology , immune system , genetics , infertility , gene , cancer

Despite ongoing progresses of IVF techniques, biomarkers predicting their outcome prior to IVF initiation are lacking. We investigated whether serum levels of the stress-inducible soluble major histocompatibility complex Class I chain-related molecule, MICA, (sMIC), a regulator of cellular immunity, can be predictive of implantation or pregnancy failure after IVF.

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