Examination of reproductive aging milestones among women who carry the FMR1premutation | Zendy

Emily G. Allen | Zendy; Amy K. Sullivan | Zendy; Michele Marcus | Zendy; Chanley M. Small | Zendy; Celia E. Dominguez | Zendy; Michael P. Epstein | Zendy; Krista Charen | Zendy; Weiya He | Zendy; Kira C. Taylor | Zendy; Stephanie L. Sherman | Zendy

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Examination of reproductive aging milestones among women who carry the FMR1premutation

Author(s) -

Emily G. Allen,

Amy K. Sullivan,

Michele Marcus,

Chanley M. Small,

Celia E. Dominguez,

Michael P. Epstein,

Krista Charen,

Weiya He,

Kira C. Taylor,

Stephanie L. Sherman

Publication year - 2007

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dem148

Subject(s) - premature ovarian insufficiency , premature ovarian failure , fmr1 , biology , genetics , oocyte , ovarian reserve , physiology , allele , medicine , infertility , pregnancy , endocrinology , gene , embryo

The fragile X premutation is characterized by a large CGG repeat track (55-199 repeats) in the 5' UTR of the FMR1 gene. This X-linked mutation leads to an increased risk for premature ovarian failure; interestingly, the association of repeat size with risk is non-linear. We hypothesize that the premutation-associated ovarian insufficiency is due to a diminished oocyte pool and examined reproductive aging milestones by repeat size group to determine if the same non-linear association is observed.

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