Exogenous growth differentiation factor 9 in oocyte maturation media enhances subsequent embryo development and fetal viability in mice | Zendy

C. X. Yeo | Zendy; Robert B. Gilchrist | Zendy; Jeremy G. Thompson | Zendy; Michelle Lane | Zendy

Open Access

Exogenous growth differentiation factor 9 in oocyte maturation media enhances subsequent embryo development and fetal viability in mice

Author(s) -

C. X. Yeo,

Robert B. Gilchrist,

Jeremy G. Thompson,

Michelle Lane

Publication year - 2007

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dem140

Subject(s) - blastocyst , oocyte , growth differentiation factor 9 , biology , andrology , inner cell mass , in vitro maturation , embryogenesis , embryo , epidermal growth factor , endocrinology , medicine , folliculogenesis , microbiology and biotechnology , cell culture , genetics

Successful oocyte in vitro maturation (IVM) would eliminate the need for hormonal stimulation used in assisted reproduction techniques. Unfortunately, oocytes matured in vitro have compromised developmental competence possibly due to disrupted oocyte-cumulus communication resulting from inappropriate levels of oocyte-secreted factors such as growth differentiation factor 9 (GDF9). Hence, the aim of this study was to investigate the effects of exogenous GDF9 during IVM of mouse oocytes on development and subsequent fetal viability.

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