Open AccessEmbryo development after successful somatic cell nuclear transfer to in vitro matured human germinal vesicle oocytes
Author(s) -
Björn Heindryckx,
Petra De Sutter,
Jan Gerris,
Marc Dhont,
Josiane Van Der Elst
Publication year - 2007
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/dem106
Subject(s) - germinal vesicle , somatic cell nuclear transfer , andrology , oocyte , in vitro maturation , blastocyst , embryo , biology , somatic cell , embryogenesis , microbiology and biotechnology , chemistry , genetics , medicine , gene
Somatic cell nuclear transfer (SCNT) involves the transfer of somatic cell nuclei into enucleated oocytes. Because human in vivo matured oocytes are scarcely available, we investigated whether in vitro matured (IVM) germinal vesicle (GV) oocytes could also support preimplantation development of human cloned embryos.