First trimester maternal serum ischaemia-modified albumin: a marker of hypoxia-ischaemia-driven early trophoblast development | Zendy

Federico Prefumo | Zendy; David Gaze | Zendy; Aris T. Papageorghiou | Zendy; Paul Collinson | Zendy; B. Thilaganathan | Zendy

Open Access

First trimester maternal serum ischaemia-modified albumin: a marker of hypoxia-ischaemia-driven early trophoblast development

Author(s) -

Federico Prefumo,

David Gaze,

Aris T. Papageorghiou,

Paul Collinson,

B. Thilaganathan

Publication year - 2007

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dem095

Subject(s) - medicine , pregnancy , gestation , interquartile range , trophoblast , hypoxia (environmental) , obstetrics , ischemia , gynecology , fetus , placenta , biology , chemistry , genetics , organic chemistry , oxygen

A hypoxic intrauterine environment is believed to play a pivotal role in physiological trophoblast development. Ischaemia-modified albumin (IMA) is used in the measurement of cardiac ischaemia. We aimed to test the hypothesis that maternal serum IMA may be elevated in early pregnancy as a measurable manifestation of intrauterine ischaemia.

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