Xenotransplantation of testicular tissue into nude mice can be used for detecting leukemic cell contamination | Zendy

Mi Hou | Zendy; Mats Andersson | Zendy; Staffan Eksborg | Zendy; Olle Söder | Zendy; Kirsi Jahnukainen | Zendy

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Xenotransplantation of testicular tissue into nude mice can be used for detecting leukemic cell contamination

Author(s) -

Mi Hou,

Mats Andersson,

Staffan Eksborg,

Olle Söder,

Kirsi Jahnukainen

Publication year - 2007

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dem085

Subject(s) - xenotransplantation , contamination , biology , andrology , immunology , transplantation , physiology , medicine , ecology

Xeno-grafting of testicular tissue may allow viable gamete maturation. This would be beneficial for prepubertal cancer patients in that it may allow restoration of fertility without the risk of a cancer relapse. However it is unknown whether cancer cells in the testicular graft can transmit the malignancy into the host animal and also if gametes can be retrieved from testicular grafts that are contaminated with malignant cells.

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