Estrogen affects post-menopausal women differently than estrogen plus progestin replacement therapy | Zendy

Richard L. Tannen | Zendy; Mark G. Weiner | Zendy; Dawei Xie | Zendy; Kurt T. Barnhart | Zendy

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Estrogen affects post-menopausal women differently than estrogen plus progestin replacement therapy

Author(s) -

Richard L. Tannen,

Mark G. Weiner,

Dawei Xie,

Kurt T. Barnhart

Publication year - 2007

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dem031

Subject(s) - estrogen , estrogen replacement therapy , progestin , medicine , estrogen therapy , hormone replacement therapy (female to male) , menopause , gynecology , endocrinology , testosterone (patch)

In the Women's Health Initiative Randomized Controlled Trial (WHI RCT), estrogen-only treatment compared with combined estrogen-progestin treatment resulted in less coronary artery disease, no increase in breast cancer and no reduction in colorectal cancer. Since we previously reasonably replicated the combined estrogen-progestin WHI RCT using the UK General Practice Research Database (GPRD), estrogen-only treatment was investigated using a similar methodology.

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