Nuclear and cytoplasmic maturation of in vitro matured human oocytes after temporary nuclear arrest by phosphodiesterase 3-inhibitor | Zendy

Leen Vanhoutte | Zendy; Petra De Sutter | Zendy; Daniela Nogueira | Zendy; Jan Gerris | Zendy; Marc Dhont | Zendy; Josiane Van Der Elst | Zendy

Open Access

Nuclear and cytoplasmic maturation of in vitro matured human oocytes after temporary nuclear arrest by phosphodiesterase 3-inhibitor

Author(s) -

Leen Vanhoutte,

Petra De Sutter,

Daniela Nogueira,

Jan Gerris,

Marc Dhont,

Josiane Van Der Elst

Publication year - 2007

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dem007

Subject(s) - germinal vesicle , cytoplasm , in vitro maturation , microbiology and biotechnology , andrology , ovarian follicle , follicular phase , biology , phosphodiesterase , oocyte , endocrinology , biochemistry , medicine , enzyme , embryo

The use of hormones for controlled ovarian stimulation results in follicular heterogeneity, with oocytes at diverse stages of nuclear and cytoplasmic development. This study evaluated the impact of temporary nuclear arrest by a specific phosphodiesterase 3-inhibitor (PDE3-I), cilostamide, on nuclear and cytoplasmic maturation of cumulus-free germinal vesicle (GV) human oocytes from controlled ovarian stimulated cycles.

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