Haplotype analysis of the estrogen receptor 1 gene in male genital and reproductive abnormalities | Zendy

Masanori Watanabe | Zendy; Rie Yoshida | Zendy; Katsuhiko Ueoka | Zendy; Katsuya Aoki | Zendy; Isoji Sasagawa | Zendy; Tomonobu Hasegawa | Zendy; Kou Sueoka | Zendy; Naoyuki Kamatani | Zendy; Yasunori Yoshimura | Zendy; Tsutomu Ogata | Zendy

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Haplotype analysis of the estrogen receptor 1 gene in male genital and reproductive abnormalities

Author(s) -

Masanori Watanabe,

Rie Yoshida,

Katsuhiko Ueoka,

Katsuya Aoki,

Isoji Sasagawa,

Tomonobu Hasegawa,

Kou Sueoka,

Naoyuki Kamatani,

Yasunori Yoshimura,

Tsutomu Ogata

Publication year - 2007

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/del513

Subject(s) - haplotype , biology , estrogen , estrogen receptor , gene , estrogen receptor alpha , genetics , genotype , cancer , breast cancer

We have recently suggested that homozygosity for a specific 'AGATA' haplotype within a approximately 50 kb linkage disequilibrium (LD) block of the gene for estrogen receptor alpha (ESR1) may raise the susceptibility to cryptorchidism by enhancing estrogenic effects of environmental endocrine disruptors (EEDs).

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