Influence of follicular fluid meiosis-activating sterol on aneuploidy rate and precocious chromatid segregation in aged mouse oocytes | Zendy

Suna Cukurcam | Zendy; I. Betzendahl | Zendy; Geert Michel | Zendy; Edgar-John Vogt | Zendy; Christa HegeleHartung | Zendy; B. Lindenthal | Zendy; Ursula Eichenlaub-Ritter | Zendy

Open Access

Influence of follicular fluid meiosis-activating sterol on aneuploidy rate and precocious chromatid segregation in aged mouse oocytes

Author(s) -

Suna Cukurcam,

I. Betzendahl,

Geert Michel,

Edgar-John Vogt,

Christa HegeleHartung,

B. Lindenthal,

Ursula Eichenlaub-Ritter

Publication year - 2006

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/del442

Subject(s) - meiosis , aneuploidy , biology , sister chromatids , oocyte , andrology , mad2 , chromatid , maturation promoting factor , follicular fluid , genetics , chromosome segregation , chromosome , medicine , embryo , apoptosis , cell cycle , gene , cyclin dependent kinase 1

Follicular fluid meiosis-activating sterol (FF-MAS) protects young oocytes from precocious chromatid separation (predivision). Reduced expression of cohesion and checkpoint proteins and predivision has been hypothesized to occur in age-related aneuploidy in oocytes.

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