Testis/sperm-specific histone 2B in the sperm of donors and subfertile patients: variability and relation to chromatin packaging | Zendy

Stephanie Singleton | Zendy; Andrei O. Zalensky | Zendy; Gustavo F. Doncel | Zendy; Mahmood Morshedi | Zendy; Irina A. Zalenskaya | Zendy

Open Access

Testis/sperm-specific histone 2B in the sperm of donors and subfertile patients: variability and relation to chromatin packaging

Author(s) -

Stephanie Singleton,

Andrei O. Zalensky,

Gustavo F. Doncel,

Mahmood Morshedi,

Irina A. Zalenskaya

Publication year - 2006

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/del439

Subject(s) - spermatozoon , sperm , chromatin , andrology , chromomycin a3 , protamine , semen , biology , staining , histone , genetics , medicine , dna , heterochromatin , heparin , biochemistry

The compaction of human sperm chromatin is the result of replacement of approximately 85% of histones with protamines. Germ-line testis/sperm-specific histone 2B (TSH2B) has been detected in only approximately 30% of mature spermatozoa. Its level in the semen of subfertile patients varies; its function is unknown. We evaluated TSH2B in the sperm samples of 23 donors and 49 subfertile patients and assessed its association with chromatin compaction status.

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