DNA damage in human sperm is related to urinary levels of phthalate monoester and oxidative metabolites | Zendy

Russ Hauser | Zendy; John D. Meeker | Zendy; Narendra P. Singh | Zendy; M.J. Silva | Zendy; Louise Ryan | Zendy; Susan Duty | Zendy; Antonia M. Calafat | Zendy

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DNA damage in human sperm is related to urinary levels of phthalate monoester and oxidative metabolites

Author(s) -

Russ Hauser,

John D. Meeker,

Narendra P. Singh,

M.J. Silva,

Louise Ryan,

Susan Duty,

Antonia M. Calafat

Publication year - 2006

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/del428

Subject(s) - phthalate , metabolite , dna damage , sperm , chemistry , comet assay , population , urine , urinary system , reproductive toxicity , endocrinology , medicine , biology , andrology , biochemistry , dna , toxicity , environmental health , organic chemistry

The ubiquitous use of phthalate esters in plastics, personal care products and food packaging materials results in widespread general population exposure. In this report, we extend our preliminary study on the relationship between urinary concentrations of phthalate metabolites and sperm DNA damage among a larger sample of men and include measurements of mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), two oxidative metabolites of di-(2-ethylhexyl) phthalate (DEHP).

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