Methylenetetrahydrofolate reductase C677T and A1298C variants do not affect ongoing pregnancy rates following IVF | Zendy

A.T. Dobson | Zendy; Richard M. Davis | Zendy; Mitchell P. Rosen | Zendy; S. Shen | Zendy; Paolo Rinaudo | Zendy; Jessica L. Chan | Zendy; Marcelle I. Cedars | Zendy

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Methylenetetrahydrofolate reductase C677T and A1298C variants do not affect ongoing pregnancy rates following IVF

Author(s) -

A.T. Dobson,

Richard M. Davis,

Mitchell P. Rosen,

S. Shen,

Paolo Rinaudo,

Jessica L. Chan,

Marcelle I. Cedars

Publication year - 2006

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/del396

Subject(s) - methylenetetrahydrofolate reductase , genotyping , pregnancy , genotype , biology , recurrent miscarriage , obstetrics , abortion , genetics , andrology , gynecology , medicine , bioinformatics , gene

There is concern that IVF could compromise normal imprinting and methylation of DNA. Methylenetetrahydrofolate reductase (MTHFR) regulates the flow of folic acid-derived, one-carbon moieties for methylation and is critical to early embryonic development. Therefore, we hypothesized that common polymorphisms in MTHFR could associate with IVF outcome.

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