Polycystic ovaries after precocious pubarche: relation to prenatal growth | Zendy

Lourdes Ibáñez | Zendy; Adriana Jaramillo | Zendy; Goya Enríquez | Zendy; E. Miró | Zendy; Abel LópezBermejo | Zendy; David B. Dunger | Zendy; Francis de Zegher | Zendy

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Polycystic ovaries after precocious pubarche: relation to prenatal growth

Author(s) -

Lourdes Ibáñez,

Adriana Jaramillo,

Goya Enríquez,

E. Miró,

Abel LópezBermejo,

David B. Dunger,

Francis de Zegher

Publication year - 2006

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/del395

Subject(s) - polycystic ovary , hyperandrogenism , anovulation , pregnancy , medicine , body mass index , hirsutism , endocrinology , gynecology , obstetrics , insulin resistance , insulin , biology , genetics

In 1998, we revealed a sequence departing from prenatal growth restraint in girls and evolving, through precocious pubarche (PP) in mid-childhood, towards anovulatory and hyperinsulinaemic hyperandrogenism. The latter condition fulfilled the criteria for the diagnosis of polycystic ovary syndrome (PCOS), which was then defined independently of the presence of polycystic ovaries (PCOs). Since 2003, the diagnosis of PCOS has been extended by adding PCO as an alternative criterion. We verified longitudinally over 28 +or- 2 years the prevalence of PCO and its potential relationship to growth before birth in a group of post-PP women (n=14, mean age=28 years; body mass index=24.3 kg/m2) belonging to the original cohort of 35 girls in whom the PP-PCOS sequence was described.

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