Toll-like receptor 4 polymorphisms and idiopathic chromosomally normal miscarriage | Zendy

Aaron F. Hirschfeld | Zendy; R. Jiang | Zendy; Wendy P. Robinson | Zendy; Deborah E. McFadden | Zendy; Stuart E. Turvey | Zendy

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Toll-like receptor 4 polymorphisms and idiopathic chromosomally normal miscarriage

Author(s) -

Aaron F. Hirschfeld,

R. Jiang,

Wendy P. Robinson,

Deborah E. McFadden,

Stuart E. Turvey

Publication year - 2006

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/del377

Subject(s) - tlr4 , single nucleotide polymorphism , genotype , biology , fetus , andrology , recurrent miscarriage , oxytocin receptor , miscarriage , receptor , pregnancy , immunology , umbilical cord , medicine , endocrinology , genetics , gene

Lipopolysaccharide (LPS or endotoxin) exposure resulting from microbial invasion of the endometrium disturbs the Th1/Th2 balance at the feto-maternal interface and has been linked to the risk of idiopathic miscarriage in a range of human and animal studies. Toll-like receptor 4 (TLR4) mediates LPS signalling, and the human TLR4 gene harbours two single-nucleotide polymorphisms (SNPs) known to reduce LPS responsiveness. We hypothesized that genetic variation altering TLR4 function may influence the risk of idiopathic pregnancy loss.

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