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There is little information about the long-term outcome of children born after ICSI. In this study, the eldest cohort of ICSI children worldwide, reaching the age of 8 years, was investigated at the prepubertal stage to monitor subsequent puberty and future fertility. To investigate possible health problems, a thorough medical and neurological examination was performed.

Medical outcome of 8-year-old singleton ICSI children (born >=32 weeks' gestation) and a spontaneously conceived comparison group