Ovarian leukocyte distribution and cytokine/chemokine mRNA expression in follicular fluid cells in women with polycystic ovary syndrome | Zendy

Rongde Wu | Zendy; Shunsaku Fujii | Zendy; Natalie K. Ryan | Zendy; Kylie H. Van der Hoek | Zendy; Melinda J. Jasper | Zendy; Ivan Sini | Zendy; Sarah A. Robertson | Zendy; Rebecca L. Robker | Zendy; Robert J. Norman | Zendy

Open Access

Ovarian leukocyte distribution and cytokine/chemokine mRNA expression in follicular fluid cells in women with polycystic ovary syndrome

Author(s) -

Rongde Wu,

Shunsaku Fujii,

Natalie K. Ryan,

Kylie H. Van der Hoek,

Melinda J. Jasper,

Ivan Sini,

Sarah A. Robertson,

Rebecca L. Robker,

Robert J. Norman

Publication year - 2006

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/del371

Subject(s) - polycystic ovary , biology , follicular fluid , cytokine , chemokine , medicine , endocrinology , immunology , inflammation , oocyte , insulin , insulin resistance , microbiology and biotechnology , embryo

Polycystic ovary syndrome (PCOS) affects 5-10% of reproductive-aged women and is commonly associated with anovulatory infertility. Leukocytes, together with granulosa cells, may contribute to the pathogenesis of PCOS via their ability to secrete an array of cytokines implicated in follicle growth. The aim of this study was to examine leukocyte subtypes in follicular phase ovaries and to quantify cytokine and chemokine mRNA expression in follicular fluid cells obtained at the time of oocyte retrieval before IVF in women with and without PCOS.

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