Effects of urinary and recombinant gonadotrophins on gene expression profiles during the murine peri-implantation period | Zendy

R.M. Sibug | Zendy; Nicole A. Datson | Zendy; A. M. I. Tijssen | Zendy; M. C. Morsink | Zendy; Jos J. de Koning | Zendy; E. R. de Kloet | Zendy; Frans M. Helmerhorst | Zendy

Open Access

Effects of urinary and recombinant gonadotrophins on gene expression profiles during the murine peri-implantation period

Author(s) -

R.M. Sibug,

Nicole A. Datson,

A. M. I. Tijssen,

M. C. Morsink,

Jos J. de Koning,

E. R. de Kloet,

Frans M. Helmerhorst

Publication year - 2006

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/del363

Subject(s) - recombinant dna , urinary system , gene expression , biology , andrology , gene chip analysis , microarray analysis techniques , gene expression profiling , microarray , endocrinology , gene , real time polymerase chain reaction , medicine , genetics

Controlled ovarian stimulation (COS) with urinary gonadotrophins but not recombinant gonadotrophins, adversely affect the implantation process. In this study, we investigated the effects of urinary and recombinant gonadotrophins on gene expression profiles at implantation sites during the mouse peri-implantation period and the possible molecular mechanisms involved in the detrimental effects of urinary gonadotrophins using microarray technology.

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