Secretory endometrium highly expresses urocortin messenger RNA and peptide: possible role in the decidualization process
Author(s) -
Michela Torricelli,
Geppino Falco,
Pasquale Florio,
Marco Rossi,
Eleonora Leucci,
Paola Viganò,
Lorenzo Leoncini,
Felice Petraglia
Publication year - 2006
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/del331
Subject(s) - decidualization , endometrium , stromal cell , medicine , endocrinology , luteal phase , biology , messenger rna , menstrual cycle , urocortin , prolactin , decidua , secretion , andrology , chemistry , follicular phase , receptor , placenta , hormone , fetus , gene , pregnancy , biochemistry , genetics
Urocortin (UCN) gene expression and synthesis have been reported in epithelial and stromal cells of the human endometrium. In this study we evaluated (i) UCN messenger RNA (mRNA) expression and peptide production in uterine specimens collected throughout the endometrial cycle, (ii) UCN secretion after decidualization of cultured human endometrial stromal cells (HESCs) and (iii) the effect of UCN on endometrial decidualization.
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