Seminal plasma and prostaglandin E2 up-regulate fibroblast growth factor 2 expression in endometrial adenocarcinoma cells via E-series prostanoid-2 receptor-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulated kinase pathway | Zendy

S. Battersby | Zendy; Kurt J. Sales | Zendy; Alistair Williams | Zendy; Richard A. Anderson | Zendy; Samantha Gardner | Zendy; Henry N. Jabbour | Zendy

Open Access

Seminal plasma and prostaglandin E2 up-regulate fibroblast growth factor 2 expression in endometrial adenocarcinoma cells via E-series prostanoid-2 receptor-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulated kinase pathway

Author(s) -

S. Battersby,

Kurt J. Sales,

Alistair Williams,

Richard A. Anderson,

Samantha Gardner,

Henry N. Jabbour

Publication year - 2006

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/del328

Subject(s) - prostaglandin e2 receptor , endocrinology , medicine , epidermal growth factor , mapk/erk pathway , biology , epidermal growth factor receptor , cancer research , receptor , signal transduction , chemistry , microbiology and biotechnology , agonist

Prostaglandin E(2) (PGE(2)) has been shown to modulate angiogenesis and tumour progression via the E-series prostanoid-2 (EP2) receptor. Endometrial adenocarcinomas may be exposed to endogenous PGE(2) and exogenous PGE(2), present at high concentration in seminal plasma.

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