Towards a non-invasive method for early detection of testicular neoplasia in semen samples by identification of fetal germ cell-specific markers | Zendy

Christina E. HoeiHansen | Zendy; Elisabeth Carlsen | Zendy; Niels Jørgensen | Zendy; Henrik Leffers | Zendy; Niels E. Skakkebæk | Zendy; Ewa RajpertDe Meyts | Zendy

Open Access

Towards a non-invasive method for early detection of testicular neoplasia in semen samples by identification of fetal germ cell-specific markers

Author(s) -

Christina E. HoeiHansen,

Elisabeth Carlsen,

Niels Jørgensen,

Henrik Leffers,

Niels E. Skakkebæk,

Ewa RajpertDe Meyts

Publication year - 2006

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/del320

Subject(s) - seminoma , semen , homeobox protein nanog , gonocyte , testicular germ cell tumor , germ cell tumors , embryonal carcinoma , biology , germ cell , fetus , andrology , pathology , medicine , embryonic stem cell , pregnancy , induced pluripotent stem cell , genetics , cellular differentiation , gene , chemotherapy

Testicular germ cell tumours (TGCTs) originate from a common precursor, carcinoma in situ (CIS). Diagnosis at the CIS stage is desirable as it minimizes the necessary treatment. A detailed clinical evaluation of an approach to detect CIS cells in the ejaculate using primordial germ cell/gonocyte markers is presented.

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