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Association study of four polymorphisms in three folate-related enzyme genes with non-obstructive male infertility
Author(s) -
HanChul Lee,
Yu-Mi Jeong,
Sook Hwan Lee,
Kwang Yul,
SeungHun Song,
Nam Keun Kim,
Kyo Won Lee,
Suman Lee
Publication year - 2006
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/del280
Subject(s) - mtrr , methylenetetrahydrofolate reductase , male infertility , azoospermia , single nucleotide polymorphism , biology , genetics , genotype , infertility , restriction fragment length polymorphism , medicine , andrology , gene , pregnancy
Three typical folate metabolism enzymes-i.e. methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MS) and MS reductase (MTRR) in the folate cycle-play a critical role in DNA synthesis and methylation reactions. We evaluated whether polymorphisms of these three enzymes are associated with non-obstructive male infertility.

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