β-Hydroxyisovalerylshikonin induces apoptosis and G0/G1 cell-cycle arrest of endometriotic stromal cells: a preliminary in vitro study | Zendy

Masakazu Nishida | Zendy; Kaei Nasu | Zendy; Tami Ueda | Zendy; Akitoshi Yuge | Zendy; Noriyuki Takai | Zendy; Hisashi Narahara | Zendy

Open Access

β-Hydroxyisovalerylshikonin induces apoptosis and G0/G1 cell-cycle arrest of endometriotic stromal cells: a preliminary in vitro study

Author(s) -

Masakazu Nishida,

Kaei Nasu,

Tami Ueda,

Akitoshi Yuge,

Noriyuki Takai,

Hisashi Narahara

Publication year - 2006

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/del270

Subject(s) - apoptosis , stromal cell , dna fragmentation , cell cycle , cancer research , medicine , cell growth , cell cycle checkpoint , flow cytometry , programmed cell death , immunology , biology , biochemistry

Most of the current medical treatments for endometriosis aim to down-regulate the estrogen activity. However, a high recurrence rate after medical treatments has been the most significant problem. Beta-hydroxyisovalerylshikonin (beta-HIVS) is an ATP non-competitive inhibitor of protein-tyrosine kinases and is considered an apoptosis-inducing agent. The aim of this study is to evaluate the effects of beta-HIVS on the proliferation, cell cycle and apoptosis of endometriotic stromal cells.

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