Ginkgolide B induces apoptosis and developmental injury in mouse embryonic stem cells and blastocysts | Zendy

WenHsiung Chan | Zendy

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Ginkgolide B induces apoptosis and developmental injury in mouse embryonic stem cells and blastocysts

Author(s) -

WenHsiung Chan

Publication year - 2006

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/del255

Subject(s) - blastocyst , embryonic stem cell , apoptosis , microbiology and biotechnology , biology , in vivo , programmed cell death , in vitro , stem cell , embryo , embryogenesis , andrology , biochemistry , medicine , genetics , gene

Ginkgolide B, the major active component of Ginkgo biloba extracts, can both stimulate and inhibit apoptotic signalling. We previously showed that ginkgolide treatment of mouse blastocysts induces apoptosis, decreases cell numbers, retards early post-implantation blastocyst development and increases early-stage blastocyst death. Here, we report more detailed examinations of the cytotoxic effects of ginkgolide B on mouse embryonic stem cells (ESCs) and blastocysts and their subsequent development in vitro and in vivo.

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