The effects of oxygen concentration and gestational age on extravillous trophoblast outgrowth in a human first trimester villous explant model | Zendy

Joanna L. James | Zendy; Peter Stone | Zendy; Larry Chamley | Zendy

Open Access

The effects of oxygen concentration and gestational age on extravillous trophoblast outgrowth in a human first trimester villous explant model

Author(s) -

Joanna L. James,

Peter Stone,

Larry Chamley

Publication year - 2006

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/del212

Subject(s) - trophoblast , decidua , gestation , placenta , andrology , gestational age , biology , endocrinology , fetus , explant culture , pregnancy , medicine , oxygen , chemistry , in vitro , biochemistry , genetics , organic chemistry

In the first trimester of human pregnancy, extravillous trophoblasts from placental villi invade the decidua temporarily occluding the spiral arteries, preventing maternal blood flow and creating a low-oxygen environment, which is believed to play an important role in the regulation of extravillous trophoblast outgrowth. This work aimed to quantify the effects of gestational age and oxygen concentration on extravillous trophoblast outgrowth.

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