Doxycycline alters the expression of inflammatory and immune-related cytokines and chemokines in human endometrial cells: implication in irregular uterine bleeding* | Zendy

Rongxiu Li | Zendy; Xiaoping Luo | Zendy; Qun Pan | Zendy; Issam Zineh | Zendy; David F. Archer | Zendy; R. Stanley Williams | Zendy; Nasser Chegini | Zendy

Open Access

Doxycycline alters the expression of inflammatory and immune-related cytokines and chemokines in human endometrial cells: implication in irregular uterine bleeding*

Author(s) -

Rongxiu Li,

Xiaoping Luo,

Qun Pan,

Issam Zineh,

David F. Archer,

R. Stanley Williams,

Nasser Chegini

Publication year - 2006

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/del206

Subject(s) - chemokine , cytokine , stromal cell , proinflammatory cytokine , tumor necrosis factor alpha , immune system , immunology , endometrium , biology , inflammation , medicine , pharmacology , endocrinology

Increased production of pro-inflammatory mediators is considered central in the manifestation of events leading to irregular uterine bleeding in progestin-only contraceptive users. Evidence suggests that in addition to its antimicrobial property, doxycycline (Dox) acts as an anti-inflammatory agent mainly through the suppression of pro-inflammatory mediators.

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