Differential infiltration of macrophages and prostaglandin production by different uterine leiomyomas | Zendy

Shoko Miura | Zendy; Khaleque Newaz Khan | Zendy; Michio Kitajima | Zendy; Koichi Hiraki | Zendy; Shingo Moriyama | Zendy; Hiroaki Masuzaki | Zendy; T. Samejima | Zendy; Akira Fujishita | Zendy; Tetsuya Ishimaru | Zendy

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Differential infiltration of macrophages and prostaglandin production by different uterine leiomyomas

Author(s) -

Shoko Miura,

Khaleque Newaz Khan,

Michio Kitajima,

Koichi Hiraki,

Shingo Moriyama,

Hiroaki Masuzaki,

T. Samejima,

Akira Fujishita,

Tetsuya Ishimaru

Publication year - 2006

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/del205

Subject(s) - myoma , medicine , endometrium , uterine fibroids , andrology , in utero , adenomyosis , pregnancy , gynecology , endometrial biopsy , leiomyoma , cd68 , uterus , immunohistochemistry , pathology , biology , fetus , genetics

The association between uterine myoma and infertility is still controversial. The anatomical defect of endometrium by uterine fibroids could be a factor for reducing pregnancy rates and increasing miscarriage rates. However, pregnancy and implantation rates were found to be significantly lower in women with intramural myomas (IMMs), when there was no deformity of uterine cavity. This could be due to other biological factors such as increased accumulation of inflammatory cells within fibroid tissue and corresponding endometrium that might impair fertility. Therefore, we tried to investigate the pattern of macrophage (Mvarphi) accumulation in different uterine fibroids and the production of chemokine and prostaglandin (PG) by these tissues.

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