Association of spermatogenic failure with decreased CDC25A expression in infertile men | Zendy

Youg-Sin Cheng | Zendy

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Association of spermatogenic failure with decreased CDC25A expression in infertile men

Author(s) -

Youg-Sin Cheng

Publication year - 2006

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/del163

Subject(s) - spermatogenesis , biology , spermatid , sperm retrieval , andrology , spermatocyte , sertoli cell , sperm , meiosis , male infertility , medicine , endocrinology , gene , genetics , infertility , pregnancy

DAZ gene family is crucial for human spermatogenesis that requires the precise co-ordination of cell cycle events. CDC25A is recognized as the downstream substrate of DAZ gene family and is thought to function on the M-phase regulation of cell cycles. We investigated the expression profiles of CDC25A in the testes of infertile men and evaluated the relationship between CDC25A levels and testicular phenotype, clinical hormonal parameters and sperm retrieval results.

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