Progesterone regulates HLA-G gene expression through a novel progesterone response element | Zendy

Shang-mian Yie | Zendy; Rong Xiao | Zendy; Clifford Librach | Zendy

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Progesterone regulates HLA-G gene expression through a novel progesterone response element

Author(s) -

Shang-mian Yie,

Rong Xiao,

Clifford Librach

Publication year - 2006

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/del126

Subject(s) - progesterone receptor , microbiology and biotechnology , transfection , chloramphenicol acetyltransferase , gene expression , electrophoretic mobility shift assay , biology , reporter gene , gene , response element , regulation of gene expression , human leukocyte antigen , promoter , antigen , genetics , estrogen receptor , cancer , breast cancer

We have previously demonstrated that progesterone has a stimulatory effect on HLA-G gene expression. Because this effect was abolished by the anti-progestin, RU486, we hypothesize that this effect is through receptor-mediated up-regulation of the HLA-G gene. The objective of this study was to explore the molecular mechanisms of this effect.

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