Role of sonic hedgehog in maintaining a pool of proliferating stem cells in the human fetal epidermis | Zendy

Jiaxi Zhou | Zendy; Liwei Jia | Zendy; Weimin Liu | Zendy; Chenglin Miao | Zendy; Shuang Liu | Zendy; Yujing Cao | Zendy; Enkui Duan | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Role of sonic hedgehog in maintaining a pool of proliferating stem cells in the human fetal epidermis

Author(s) -

Jiaxi Zhou,

Liwei Jia,

Weimin Liu,

Chenglin Miao,

Shuang Liu,

Yujing Cao,

Enkui Duan

Publication year - 2006

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/del086

Subject(s) - cyclopamine , smoothened , sonic hedgehog , biology , microbiology and biotechnology , epidermis (zoology) , stem cell , hedgehog signaling pathway , morphogenesis , epidermal growth factor , medicine , endocrinology , signal transduction , receptor , anatomy , biochemistry , gene

The mammalian epidermis is maintained by the ongoing proliferation of a subpopulation of keratinocytes known as epidermal stem cells. Sonic hedgehog (Shh) can regulate morphogenesis of hair follicles and several types of skin cancer, but the effect of Shh on proliferation of human putative epidermal stem cells (HPESCs) is poorly understood.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research