Death receptor and mitochondrial pathways are involved in germ cell apoptosis in an experimental model of autoimmune orchitis | Zendy

María Susana Theas | Zendy; Claudia Rival | Zendy; Sylvia Dietrich | Zendy; Vanesa A. Guazzone | Zendy; L. Lustig | Zendy

Open Access

Death receptor and mitochondrial pathways are involved in germ cell apoptosis in an experimental model of autoimmune orchitis

Author(s) -

María Susana Theas,

Claudia Rival,

Sylvia Dietrich,

Vanesa A. Guazzone,

L. Lustig

Publication year - 2006

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/del066

Subject(s) - apoptosis , biology , western blot , orchitis , endocrinology , medicine , microbiology and biotechnology , germ cell , fas ligand , caspase 3 , caspase , mitochondrion , cytochrome c , endoplasmic reticulum , andrology , programmed cell death , pathology , biochemistry , gene

Studies on experimental autoimmune orchitis (EAO) have helped to elucidate immunological mechanisms involved in testicular damage. We previously demonstrated that EAO is characterized by lymphomononuclear cell infiltrates and apoptosis of spermatocytes and spermatids expressing Fas and TNFR1. The aim of this work was to characterize the pathways involved in germ cell apoptosis in EAO and to determine the involvement of the Bcl-2 protein family in this process.

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