Treatment with anti-TNF monoclonal antibody (c5N) reduces the extent of induced endometriosis in the baboon | Zendy

Henrik Falconer | Zendy; J.M. Mwenda | Zendy; Daniel Chai | Zendy; Carrie Wagner | Zendy; X.-Y. R. Song | Zendy; Attila Mihalyi | Zendy; Péter Simsa | Zendy; Cleophas Kyama | Zendy; Freddy Cornillie | Zendy; Agneta Bergqvist | Zendy; Gerald M. Fried | Zendy; Thomas D’Hooghe | Zendy

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Treatment with anti-TNF monoclonal antibody (c5N) reduces the extent of induced endometriosis in the baboon

Author(s) -

Henrik Falconer,

J.M. Mwenda,

Daniel Chai,

Carrie Wagner,

X.-Y. R. Song,

Attila Mihalyi,

Péter Simsa,

Cleophas Kyama,

Freddy Cornillie,

Agneta Bergqvist,

Gerald M. Fried,

Thomas D’Hooghe

Publication year - 2006

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/del044

Subject(s) - baboon , endometriosis , placebo , medicine , laparoscopy , lesion , menstrual cycle , monoclonal antibody , gastroenterology , urology , surgery , pathology , antibody , immunology , hormone , alternative medicine

Inflammatory cytokines, including interleukin (IL)-1, IL-6, IL-8 and tumour necrosis factor-alpha (TNF-alpha), are important in the pathogenesis of endometriosis. We assessed the efficacy of anti-TNF monoclonal antibody (mAb, c5N), known to prevent induced endometriosis in baboons, in reducing established endometriosis in baboons.

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