Estrogen receptor 1 haplotype does not regulate oral contraceptive-induced changes in haemostasis and inflammation risk factors for venous and arterial thrombosis | Zendy

Moniek P.M. de Maat | Zendy; ElseMarie Bladbjerg | Zendy; Cornelis Kluft | Zendy; Ulrich Winkler | Zendy; Hans Rekers | Zendy; Sven O. Skouby | Zendy; Jørgen Jespersen | Zendy

Open Access

Estrogen receptor 1 haplotype does not regulate oral contraceptive-induced changes in haemostasis and inflammation risk factors for venous and arterial thrombosis

Author(s) -

Moniek P.M. de Maat,

ElseMarie Bladbjerg,

Cornelis Kluft,

Ulrich Winkler,

Hans Rekers,

Sven O. Skouby,

Jørgen Jespersen

Publication year - 2006

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/del015

Subject(s) - haplotype , estrogen , venous thrombosis , thrombosis , estrogen receptor , medicine , endocrinology , plasminogen activator inhibitor 1 , plasminogen activator , genotype , biology , genetics , gene , breast cancer , cancer

Administration of oral contraceptives (OCs) has profound effects on the plasma levels of haemostasis and inflammation variables, resulting in an increased thrombosis risk. Individuals show large differences in the response of these variables to OCs. Polymorphism in the estrogen receptor-1 (ER1) gene may explain part of this inter-individual response.

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