The expression of Abl interactor 2 in leiomyoma and myometrium and regulation by GnRH analogue and transforming growth factor-β | Zendy

Xiaoping Luo | Zendy; E. Levens | Zendy; R. Stanley Williams | Zendy; Nasser Chegini | Zendy

Open Access

The expression of Abl interactor 2 in leiomyoma and myometrium and regulation by GnRH analogue and transforming growth factor-β

Author(s) -

Xiaoping Luo,

E. Levens,

R. Stanley Williams,

Nasser Chegini

Publication year - 2006

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/del011

Subject(s) - myometrium , leiomyoma , follicular phase , menstrual cycle , endocrinology , medicine , immunohistochemistry , transforming growth factor , connective tissue , endometrium , blot , uterus , biology , pathology , hormone , gene , biochemistry

Abelson (Abl) interactor 2 (Abi-2) has been considered as a key regulator of cell/tissue structural organization and is differentially expressed in leiomyomas. The objective of this study was to evaluate the expression of Abi-2 in leiomyoma/myometrium during the menstrual cycle and following GnRH analogue (GnRHa) therapy, as well as regulation by transforming growth factor (TGF)-beta1 in leiomyoma and myometrial smooth muscle cells (LSMC and MSMC).

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