Estrogen receptor α promoter polymorphism: stronger estrogen action is coupled with lower sperm count | Zendy

E. Guarducci | Zendy; Francesca Nuti | Zendy; Lucia Becherini | Zendy; Mario Rotondi | Zendy; Giancarlo Balercia | Zendy; Gianni Forti | Zendy; Csilla Krausz | Zendy

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Estrogen receptor α promoter polymorphism: stronger estrogen action is coupled with lower sperm count

Author(s) -

E. Guarducci,

Francesca Nuti,

Lucia Becherini,

Mario Rotondi,

Giancarlo Balercia,

Gianni Forti,

Csilla Krausz

Publication year - 2006

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dei439

Subject(s) - sperm , biology , genotype , allele , male infertility , estrogen , estrogen receptor , infertility , medicine , endocrinology , estrogen receptor alpha , andrology , genetics , gene , pregnancy , cancer , breast cancer

Although the importance of estrogens in male reproduction is indisputable, little attention has been paid to the role of estrogen receptor (ER) gene mutations in male infertility. Significant correlation between (TA)n repeat allelic variants and lumbar bone mineral density was previously observed in the promoter region of the ERalpha gene, indicating that allelic combinations with higher number of (TA)n repeats are functionally more active genetic variants.

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